タイトル

開講年度 開講学部等
2026 大学院共同獣医学研究科（博士課程）
開講学期 曜日時限 授業形態 AL（アクティブ・ラーニング）ポイント
後期 集中 講義 2.0
時間割番号 科目名[英文名] 使用言語 単位数
5082013140 臨床獣医学特別講義（獣医腫瘍免疫代謝学特別講義)[Clinical Veterinary Medicine Special Lecture (Tumor Immunometabolism in Veterinary Medicine)] 日本語 2
担当教員（責任）[ローマ字表記] メディア授業
伊賀瀨 雅也[IGASE Masaya] ー
担当教員[ローマ字表記]
伊賀瀨 雅也　[IGASE Masaya]
特定科目区分   対象学生   対象年次  
ディプロマ・ポリシーに関わる項目 カリキュラムマップ(授業科目とDPとの対応関係はこちらから閲覧できます)
授業の目的と概要
This work aims to consolidate the fundamentals of tumor immunology and tumor metabolism—including glycolysis, lactate metabolism, hypoxia response, lipid metabolism, amino acid metabolism, and iron metabolism—to deepen the understanding of immune cell regulation within the tumor microenvironment (TME/TIME). Furthermore, it reviews the impact of metabolism on therapeutic response, resistance, and adverse events in clinical applications such as immune checkpoint blockade, cytokine therapy, cancer vaccines, and cellular therapy, ultimately bridging these insights to research and clinical practice in veterinary medicine.
授業の到達目標
To comprehensively learn and master the fields of tumor immunology and immunometabolism.
To evaluate and analyze oncology from an immunological perspective.
To pursue my strong interest in tumor immunometabolism, firmly rooted in a clinical viewpoint.
授業計画
【全体】
To systematically study tumor immunology and immunometabolism using Immuno-Pedia (Yodosha), Cancer Immuno-Pedia (Yodosha), Standard Immunology (Igaku-Shoin), and recent scientific literature. For each session, students/participants will read the designated papers (reviews/original articles) or assigned pages from the reference books and submit an A4-sized report summarizing the key points, including the background, hypothesis, methods, results, limitations, and future directions.
項目 内容 授業時間外学習 備考
第1回 General Overview Learn the fundamentals of immunology and oncology Complete one hour of preparatory study in accordance with the lesson plan.
第2回 Tumor metabolic reprogramming Learn about the Warburg effect, metabolic plasticity, and more. Complete one hour of preparatory study in accordance with the lesson plan.
第3回 T cell metabolism and function Learning about activation, exhaustion, memory, and mTOR/AMPK Complete one hour of preparatory study in accordance with the lesson plan.
第4回 Metabolism of tumor-associated macrophages/myeloid cells Learn the fundamentals of immunosuppressive cells. Complete one hour of preparatory study in accordance with the lesson plan.
第5回 Lactate metabolism and immunosuppression Study metabolism and immunosuppression, focusing on MCT1/4, acidic environments, and lactate metabolism. Complete one hour of preparatory study in accordance with the lesson plan.
第6回 Hypoxic response and immunity Study the HIF pathway, blood vessels, invasion, and related aspects regarding the items listed on the left. Complete one hour of preparatory study in accordance with the lesson plan.
第7回 Lipid Metabolism and Immunity Learn the concepts of FAO, lipid peroxidation, and ferroptosis regarding the items listed on the left. Complete one hour of preparatory study in accordance with the lesson plan.
第8回 Amino acid metabolism Study the topics listed on the left, focusing on Gln, Trp/IDO, Arg, Ser/Gly, and others. Complete one hour of preparatory study in accordance with the lesson plan.
第9回 Iron metabolism, redox, and cell death Learn about the topics listed on the left, focusing on ROS and ferroptosis. Complete one hour of preparatory study in accordance with the lesson plan.
第10回 Immune Checkpoints and Metabolism Regarding the topics listed on the left, the study will focus on PD-1/PD-L1, CTLA-4, and metabolic reprogramming. Complete one hour of preparatory study in accordance with the lesson plan.
第11回 Cytokine Therapy and Metabolism Study the topics listed on the left, focusing on aspects such as toxicity and metabolism, with particular attention to IL-2, IL-12, and related substances. Complete one hour of preparatory study in accordance with the lesson plan.
第12回 Radiation, Chemotherapy and metabolism Learn about immunogenic cell death. Complete one hour of preparatory study in accordance with the lesson plan.
第13回 Case Studies in Veterinary Oncology: Immunometabolism in Canine and Feline Tumors Study the topics listed on the left, focusing on the latest research papers. Complete one hour of preparatory study in accordance with the lesson plan.
第14回 Biomarker and Translational Research Study the topics listed on the left, focusing on the latest research papers. Complete one hour of preparatory study in accordance with the lesson plan.
第15回 Overview: How to Formulate a Research Hypothesis Present individual research topics. Complete one hour of preparatory study in accordance with the lesson plan.
※AL（アクティブ・ラーニング）欄に関する注
・授業全体で、AL（アクティブ・ラーニング）が占める時間の割合を、それぞれの項目ごとに示しています。
・A〜Dのアルファベットは、以下の学修形態を指しています。
【A：グループワーク】、【B：ディスカッション・ディベート】、【C：フィールドワーク（実験・実習、演習を含む）】、【D：プレゼンテーション】
A: 5%　B: 5%　C: 5%　D: 5%
成績評価法
Report 100%
教科書にかかわる情報
備考
See above
参考書にかかわる情報
備考
See above
メッセージ
Please be sure to contact the instructor in charge before registering for the course.
キーワード
持続可能な開発目標（SDGs）

  • 質の高い教育をみんなに
(教育)すべての人に包摂的かつ公正な質の高い教育を確保し、生涯学習の機会を促進する。
関連科目
履修条件
連絡先
m.igase@yamaguchi-u.ac.jp
オフィスアワー
Anytime

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